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Is HLA Class II Profile Relevant for the Study of Large‐Scale Differentially Expressed Genes in Type 1 Diabetes Mellitus Patients?
Author(s) -
RASSI DIANE M.,
JUNTA CRISTINA M.,
FACHIN ANA L.,
SANDRINGARCIA PAULA,
MELLO STEPHANO S.,
FERNANDES ANA P.M.,
DEGHAIDE NEIFE N.H.S.,
FOSSFREITAS MARIA C.,
FOSS MILTON C.,
SAKAMOTOHOJO ELZA T.,
PASSOS GERALDO A.S.,
DONADI EDUARDO A.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1375.046
Subject(s) - allele , major histocompatibility complex , human leukocyte antigen , genetics , dendrogram , gene , biology , immunology , antigen , medicine , population , environmental health , genetic diversity
We have previously identified 30 differentially expressed genes when comparing recently diagnosed type 1 diabetes mellitus (DM‐1) patients and controls paired for sex, age, and ethnic background. In this article we performed the hierarchical clustering of these genes taking into account the human‐leukocyte‐antigen (HLA)‐DRB1/DQB1 profile. The dendrogram obtained using the Cluster program grouped patients and controls into three clusters, one including individuals with no susceptibility alleles, another including individuals with at least three susceptibility alleles, and a third intermingling susceptibility/protective alleles. In addition to other variables, the results of the present article suggest that the major histocompatibility complex (MHC) class II profile may be of relevance for the study of a large‐scale differentially expressed genes.