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New Members of the Interleukin‐12 Family of Cytokines: IL‐23 and IL‐27 Modulate Autoimmune Diabetes
Author(s) -
MENSAHBROWN E.P.K.,
SHAHIN A.,
ALSHAMSI M.,
LUKIC M.L.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1375.024
Subject(s) - mononuclear cell infiltration , islet , peripheral blood mononuclear cell , streptozotocin , infiltration (hvac) , endocrinology , diabetes mellitus , medicine , interleukin , regimen , apoptosis , immune system , proinflammatory cytokine , weight loss , body weight , cytokine , chemistry , immunology , inflammation , obesity , in vitro , biochemistry , physics , thermodynamics
Multiple low doses of streptozotocin (5 × 40 mg/kg) given to susceptible male C57BL6 mice induced delayed and sustained hyperglycemia accompanied by body weight loss, mononuclear cell infiltration in the islet, and apoptosis of β cells. Shorter regimes (4 × 40 mg/kg) did not have such effect. Administration of IL‐23 at a dose of 400 ng/mL for 10 consecutive days concomitantlywith this subdiabetogenic regimen of STZ, however, induced significant hyperglycemia, weight loss, and mononuclear cellular infiltration. The same regimen of IL‐27 in duced milder effect on glycemia and no weight loss inspite of a massive peri‐islet and intra‐islet infiltration of mononuclear cells. The molecular mechanisms underlying the actions of these cytokines on diabetogenesis is under study.