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MHC‐Linked Susceptibility to Type 1 Diabetes in the NOD Mouse
Author(s) -
FUJISAWA TOMOMI,
IKEGAMI HIROSHI,
NOSO SHINSUKE,
YAMAJI KAORI,
NOJIMA KOJI,
BABAYA NARU,
ITOIBABAYA MICHIKO,
HIROMINE YOSHIHISA,
KOBAYASHI MISATO,
MAKINO SUSUMU,
OGIHARA TOSHIO
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1375.017
Subject(s) - nod , major histocompatibility complex , nod mice , biology , immunology , mhc class ii , mhc class i , genetics , antigen , gene
Although major histocompatibility complex (MHC)‐linked susceptibility is the strongest component, recent studies demonstrated that MHC‐linked susceptibility to type 1 diabetes consists of multiple components both in humans and non‐obese diabetic (NOD) mouse. In the NOD mouse, Idd16 has been mapped to the region adjacent to, but distinct from Idd1 in the MHC class II region. Establishment of subcongenic NOD.CTS ‐H2 lines that possess the same MHC class II as the NOD mouse but non‐NOD‐derived chromosomal region in its adjacent regions, would facilitate further narrowing down of the localization of Idd16 .