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Contribution of Class III MHC to Susceptibility to Type 1 Diabetes in the NOD Mouse
Author(s) -
YAMAJI KAORI,
IKEGAMI HIROSHI,
FUJISAWA TOMOMI,
NOSO SHINSUKE,
NOJIMA KOJI,
BABAYA NARU,
ITOIBABAYA MICHIKO,
KOBAYASHI MISATO,
HIROMINE YOSHIHISA,
MAKINO SUSUMU,
OGIHARA TOSHIO
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1375.016
Subject(s) - congenic , major histocompatibility complex , nod , nod mice , mhc class i , biology , type 1 diabetes , immunology , recombinant dna , mhc class ii , diabetes mellitus , genetics , antigen , gene , endocrinology
A recombinant major histocompatibility complex (MHC) with the same class III region as the NOD mouse, but different class II region from the NOD mouse was identified in the NON mouse, and NOD mice congenic for this recombinant MHC, NOD.NON‐ H2 , was established. None of the congenic mice homozygous for the NON MHC developed type 1 diabetes, indicating that the NOD MHC is necessary for the development of type 1 diabetes. A small portion of MHC heterozygotes developed late‐onset type 1 diabetes, suggesting the contribution of class III MHC to type 1 diabetes susceptibility.