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Experimental Infections in Dogs with Ehrlichia canis Strain Borgo 89
Author(s) -
JOURETGOURJAULT STÉPHANIE,
PARZY DANIEL,
DAVOUST BERNARD
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1374.132
Subject(s) - canis , strain (injury) , pathogenicity , serology , virulence , ehrlichia canis , ehrlichia , biology , ehrlichiosis , virology , autopsy , microbiology and biotechnology , medicine , immunology , pathology , antibody , gene , genetics , paleontology , tick , anatomy
This study attemps to clarify the virulence and the pathogenicity of the Borgo 89 strain of Ehrlichia canis isolated from a sick dog in Corsica (France). Four unscathed beagles were intravenously injected with an inoculum of leukocytes infected with the Borgo 89 strain and the animals were examined daily for clinical signs of disease, and blood samples were drawn at frequent intervals for biochemical and hematologic assessment. Serologic (IFI) and PCR assays were also carried out. The results at autopsy are presented in this paper, leading to the conclusion that the Borgo 89 strain has a pathogenicity comparable to that of the known strains. However, the discovery of a case of completely unapparent infection raises the question of a possible individual immunization whose origin remains unexplained.