Premium
Corpuscular Antigenic Microarray for the Serodiagnosis of Blood Culture–Negative Endocarditis
Author(s) -
SAMSON LAURENT,
DRANCOURT MICHEL,
CASALTA JEANPAUL,
RAOULT DIDIER
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1374.119
Subject(s) - serology , fastidious organism , endocarditis , coxiella burnetii , blood culture , bartonella , microbiology and biotechnology , biology , multiplex , antigen , virology , immunology , medicine , antibody , bacteria , bioinformatics , genetics , antibiotics
Blood culture–negative endocarditis is due to fastidious bacteria, including Coxiella burnetii and Bartonella spp. Diagnosis of such infection relies on serology and microimmunofluorescence is therefore the reference method. We developed a multiplex serology test featuring automatic incubation and reading and incorporating internal controls. Preliminary results indicate that this new serologic test is valuable for the rapid, automated serological diagnosis of blood culture–negative endocarditis.