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Evaluation of IgG Antibody Response against Rickettsia conorii and Rickettsia slovaca in Patients with DEBONEL/TIBOLA
Author(s) -
SANTIBÁÑEZ S.,
IBARRA V.,
PORTILLO A.,
BLANCO J.R.,
De ARTOLA V. MARTÍNEZ,
GUERRERO A.,
OTEO J.A.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1374.113
Subject(s) - rickettsia conorii , spotted fever , boutonneuse fever , rickettsiosis , serology , antigen , virology , rickettsia , antibody , medicine , biology , microbiology and biotechnology , immunology , virus
The aim of the study was to determine the IgG antibody response to spotted fever group Rickettsia (SFGR) R. conorii and R. slovaca , and its specificity and sensitivity in patients with DEBONEL/TIBOLA. A prospective study of 31 patients with DEBONEL was carried out from January 2001 to May 2004. The SFGR serology testing (IgG IFA) for the diagnosis of DEBONEL/TIBOLA showed 61% sensitivity and 100% specificity. The R. slovaca antigen allowed the diagnoses in 18 of the 31 patients (58%), and 17 patients (55%) were diagnosed with this disease using R. conorii antigen. Therefore, using R. slovaca as antigen did not improve the sensitivity of the assay.