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SEPPIC Vaccine Adjuvants for Poultry
Author(s) -
DUPUIS L.,
ASCARATEIL S.,
AUCOUTURIER J.,
GANNE V.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1373.024
Subject(s) - pasteurella multocida , antibody response , antigen , inactivated vaccine , chemistry , biology , virology , vaccination , immunology , bacteria , genetics
Two inactivated antigens (Newcastle and Pasteurella Multocida ) were formulated with different adjuvants and tested in two separate experiments in poultry. Oil formulations constituting water in oil (W/O) or water in oil in water (W/O/W) emulsions were assessed for antibody response, protection, local reactions, and vaccine physicochemical parameters. Robust, efficacious, and safe formulations were obtained with W/O formulations whereas W/O/W was especially safe with maintained efficacy. Results show that it is possible to improve traditional Tween Span formulations for safety and efficacy parameters by using Montanide™ ISA 70 for W/O formulations and Montanide™ ISA 206 for W/O/W when safety is the priority.