SEPPIC Vaccine Adjuvants for Poultry | Zendy

DUPUIS L. | Zendy; ASCARATEIL S. | Zendy; AUCOUTURIER J. | Zendy; GANNE V. | Zendy

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SEPPIC Vaccine Adjuvants for Poultry

Author(s) -

DUPUIS L.,

ASCARATEIL S.,

AUCOUTURIER J.,

GANNE V.

Publication year - 2006

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1196/annals.1373.024

Subject(s) - pasteurella multocida , antibody response , antigen , inactivated vaccine , chemistry , biology , virology , vaccination , immunology , bacteria , genetics

Two inactivated antigens (Newcastle and Pasteurella Multocida ) were formulated with different adjuvants and tested in two separate experiments in poultry. Oil formulations constituting water in oil (W/O) or water in oil in water (W/O/W) emulsions were assessed for antibody response, protection, local reactions, and vaccine physicochemical parameters. Robust, efficacious, and safe formulations were obtained with W/O formulations whereas W/O/W was especially safe with maintained efficacy. Results show that it is possible to improve traditional Tween Span formulations for safety and efficacy parameters by using Montanide™ ISA 70 for W/O formulations and Montanide™ ISA 206 for W/O/W when safety is the priority.

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