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Association Study of the Tumor Necrosis Factor‐α Gene and Its 1A Receptor Gene with Methamphetamine Dependence
Author(s) -
NOMURA A.,
UJIKE H.,
TANAKA Y.,
KISHIMOTO M.,
OTANI K.,
MORITA Y.,
MORIO A.,
HARANO M.,
INADA T.,
YAMADA M.,
KOMIYAMA T.,
HORI T.,
SEKINE Y.,
IWATA N.,
SORA I.,
IYO M.,
OZAKI N.,
KURODA S.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1369.011
Subject(s) - meth , methamphetamine , tumor necrosis factor alpha , exon , haplotype , gene , allele , receptor , genetic association , biology , cytokine , genetics , immunology , cancer research , medicine , single nucleotide polymorphism , genotype , pharmacology , chemistry , monomer , organic chemistry , acrylate , polymer
Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor‐α (TNF‐α) mRNA in some brain regions and that TNF‐α blocked METH neurotoxicity and rewarding effects suggest TNF‐α, a multifunctional pro‐inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF‐α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of ‐308G>A and ‐857C>T in the promotor region of the TNF‐α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR‐SF1A), were analyzed in patients with METH dependence ( n = 185) and healthy controls ( n = 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF‐α or TNFR‐SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF‐α gene and its receptor genes may not be involved in individual vulnerability to METH dependence.