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Use of Bi‐Allelic Insertion/Deletion Polymorphisms as a Positive Control for Fetal Genotyping in Maternal Blood
Author(s) -
PAGECHRISTIAENS GODELIEVE C.M.L.,
BOSSERS BERNADETTE,
VAN DER SCHOOT C. ELLEN,
DE HAAS MASJA
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1368.016
Subject(s) - genotyping , fetus , allele , biology , genetics , genotype , pregnancy , gene
Amplification of fetal DNA in maternal plasma is a new way for non‐invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi‐allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal “disease” sequence.