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Occurrence of Neutrophil Extracellular DNA Traps (NETs) in Pre‐Eclampsia
Author(s) -
GUPTA ANURAG,
HASLER PAUL,
GEBHARDT STEPHAN,
HOLZGREVE WOLFGANG,
HAHN SINUHE
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1368.015
Subject(s) - neutrophil extracellular traps , syncytiotrophoblast , extracellular , eclampsia , dna , intervillous space , placenta , chemistry , immunology , microbiology and biotechnology , pregnancy , biology , fetus , genetics , biochemistry , inflammation
Manifest pre‐eclampsia is associated with activation of peripheral neutrophils as well as elevations in maternal cell‐free DNA. For this reason, we were very intrigued by recent reports indicating that activated circulatory neutrophils secrete nuclear DNA to generate extracellular DNA lattices, termed NETs (neutrophil extracellular traps). Our preliminary data indicate that placental syncytiotrophoblast microparticles, which are released in elevated amounts in pre‐eclampsia, can induce NETs in isolated neutrophils. Furthermore, we found evidence for the increased presence of NETs directly in the intervillous space of pre‐eclamptic placentae. Therefore, these newly discovered entities may be implicated in the underlying etiology of this disorder.