Premium
Interleukin‐6
Author(s) -
MASTORAKOS GEORGE,
ILIAS IOANNIS
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1366.021
Subject(s) - chemistry
The hypothalamic‐pituitary‐adrenal (HPA) axis and the proinflammatory cytokines (and interleukin‐6 [IL‐6] in particular) are enmeshed in the response to somatic stress, either in health or in acute or chronic disease. Usually IL‐6 is elevated in states of septic (such as sepsis) or aseptic inflammation (such as rheumatoid arthritis). Exercise is a form of somatic stress. Local tissue IL‐6 elevation is noted during shorter and less intense exercise, whereas brief peripheral IL‐6 “bursts” are observed with longer and more intense exercise. Therapeutic interventions that target IL‐6 or its soluble receptor are currently assessed, with an emphasis on autoimmune diseases and inflammatory conditions.