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Insulin‐Like Growth Factor–1 Isoform mRNA Expression in Women with Endometriosis
Author(s) -
MILINGOS DIMITRIOS,
KATOPODIS HARALAMPOS,
MILINGOS SPYROS,
PROTOPAPAS ATHANASIOS,
CREATSAS GEORGE,
MICHALAS STELIOS,
ANTSAKLIS ARIS,
KOUTSILIERIS MICHAEL
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1365.042
Subject(s) - endometriosis , gene isoform , insulin like growth factor , endometrium , growth factor , alternative splicing , pathogenesis , medicine , endocrinology , cyst , cancer research , biology , receptor , gene , pathology , biochemistry
Pathogenesis of endometriosis involves growth factors, which are synthesized locally. Insulin‐like growth factor‐1 (IGF‐1) prevents apoptosis and has mitogenic action on endometrial cells. The IGF‐1 gene undergoes alternative splicing and results in three isoforms (IGF‐1Ea, IGF‐1Eb, and IGF‐1Ec or MGF). We analyzed the mRNA expression of IGF‐1 isoforms in tissue samples of eutopic endometrium and endometriotic cyst obtained during laparoscopy from women with endometriosis. We documented that all three IGF‐1 isoforms are expressed in both eutopic endometrium and ovarian endometrioma. Furthermore, we documented a significant decrease in all IGF‐1 isoform expression in endometriotic cyst compared to endometrium of women with endometriosis. The reduction may correlate with the disease status and presence of fibrotic inactive tissue found in late stages of the disease.