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Preimplantation Genetic Diagnosis
Author(s) -
MAROULIS GEORGE B.,
KOUTLAKI NIKOLETTA
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1365.023
Subject(s) - implantation failure , embryo , in vitro fertilisation , identification (biology) , preimplantation genetic diagnosis , pregnancy , genetic diagnosis , biology , genetic testing , advanced maternal age , obstetrics , genetics , medicine , andrology , gynecology , gene , fetus , infertility , botany
Preimplantion genetic diagnosis (PGD) is now used for identification of gene and chromosomal defects in embryos. In this article we describe its use primarily for identification of chromosomal defects in women with recurrent abortions, repeated in vitro fertilization (IVF) failure, and advanced maternal age. In all these situations there is increase in chromosomal defects. The identification of normal embryos and the elimination of abnormal embryos are argued to be helpful in increasing implantation and pregnancy rates in these women.