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Interleukin‐1β as a Mechanism for Stress‐Induced Startle Suppression in Females
Author(s) -
BECK KEVIN D.,
SERVATIUS RICHARD J.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1364.058
Subject(s) - moro reflex , endocrinology , fear potentiated startle , medicine , startle response , responsivity , mechanism (biology) , psychology , reflex , physics , amygdala , optoelectronics , fear conditioning , photodetector , quantum mechanics
Startle measures were taken 2 h following a systemic injection of interleukin‐1β (IL‐1β) (3 μg/kg) to intact or ovariectomy (OVX) female rats.Changes in startle responsivity (reduced startle magnitude) were evident in intact IL‐1β‐treated rats, despite no significant effects on startle sensitivity (number of elicited startles). No significant changes in startle sensitivity or responsivity were evident in IL‐1β‐treated OVX rats. These results are discussed as a possible mechanism for stress‐induced suppression of startle responsivity seen in intact female rats.