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Oxidative Reactive Species in Cell Injury: Mechanisms in Diabetes Mellitus and Therapeutic Approaches
Author(s) -
FRIDLYAND LEONID E.,
PHILIPSON LOUIS H.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1363.019
Subject(s) - reactive oxygen species , oxidative stress , intracellular , antioxidant , diabetes mellitus , microbiology and biotechnology , reactive nitrogen species , cell injury , oxidative phosphorylation , chemistry , medicine , biology , apoptosis , biochemistry , endocrinology
A bstract : Mammalian cells are continuously subject to insult from reactive species. Most of the pathogenic mechanisms that have been considered to date reflect overproduction of reactive oxygen species (ROS) or a peculiar failure in intracellular defenses against ROS. We have attempted to consider briefly the most important mechanisms of ROS production, defense, and reactive species‐induced cell damage and approaches to therapy, focusing on the example of diabetes mellitus. An improved understanding of these mechanisms should facilitate development of antioxidant intervention strategies leading to reduction in diseases associated with oxidative stress.