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Cellular Response to DNA Damage
Author(s) -
KAO JOHNNY,
ROSENSTEIN BARRY S.,
PETERS SHEILA,
MILANO MICHAEL T.,
KRON STEPHEN J.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1363.012
Subject(s) - dna damage , dna repair , nucleotide excision repair , postreplication repair , homologous recombination , dna mismatch repair , biology , dna damage repair , base excision repair , dna , g2 m dna damage checkpoint , microbiology and biotechnology , epigenetics , genetics , computational biology , gene , cell cycle checkpoint , cell cycle
A bstract : Eukaryotic cells, from yeast to man, possess evolutionarily conserved mechanisms to accurately and efficiently repair the overwhelming majority of DNA damage, thereby ensuring genomic integrity. Important repair pathways include base excision repair, nucleotide excision repair, mismatch repair, non‐homologous end‐joining, and homologous recombination. Defects in DNA repair processes generally result in susceptibility to cancer and, often, abnormalities in multiple organ systems. While signal transduction pathways have been intensely studied, epigenetic changes occurring in response to DNA damage are rapidly increasing in importance. Effective radiation and chemotherapy sensitization could result from selective inhibition of DNA repair in tumor cells. DNA damage repair is a dynamic field of research where the fruits of basic research often have important clinical implications.