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Rationale for T Cell Inhibition by Cyclosporin A in Major Autoimmune Diseases
Author(s) -
FERRACCIOLI G.F,
TOMIETTO P.,
SANTIS M.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1361.110
Subject(s) - calcineurin , immunology , inflammation , t cell , autoimmune disease , antigen presentation , biology , immune system , medicine , transplantation , antibody , surgery
A bstract : T cells exert a fundamental role in different autoimmune chronic inflammatory diseases. The low‐affinity autoreactive T cell clones provide the first amplification loop after the antigen (AgX) presentation, and if not counterregulated by the T regulatory cells (Treg), they maintain the inflammation and predispose to organ damage. Interrupting the T cell amplification loop through calcineurin antagonists leads to maintenance of the whole process under the autoimmune threshold.