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Removal of Pathogenic Autoantibodies by Immunoadsorption
Author(s) -
HERSHKO ALON Y.,
NAPARSTEK YAAKOV
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1361.108
Subject(s) - autoantibody , immunoadsorption , epitope , immunology , autoimmunity , antigen , antibody , medicine , computational biology , biology
A bstract : Autoimmune diseases result from disrupted tolerance to self‐antigens and subsequent damage to tissues and organs. In several diseases, specific autoantibodies have been either proved or suspected to play a role in this process. Consequently, several strategies have been devised in an attempt to discard the destructive immunoglobulins. Currently, both nonselective and epitope‐specific methods are applied in several diseases. In this review, we provide a summary of the available data on elimination of pathogenic autoantibodies and discuss the advantages and pitfalls of the different approaches.