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Apoptosis in Human Skin: Role in Pathogenesis of Various Diseases and Relevance for Therapy
Author(s) -
REEFMAN ESTHER,
LIMBURG PIETER C.,
KALLENBERG CEES G. M.,
BIJL MARC
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1361.046
Subject(s) - pathogenesis , apoptosis , relevance (law) , medicine , immunology , bioinformatics , biology , genetics , political science , law
A bstract : Cell death by apoptosis is a physiological process that enables the elimination of cells without causing an inflammatory response. In self‐renewing tissue like the epidermal layers of the skin, cell numbers are tightly regulated by a delicate balance between proliferation, differentiation, and cell death. Besides cell death by terminal differentiation in normal skin, cell death can also be induced by exposure to sunlight. This paper will review the different forms of cell death in the skin and discuss the role of apoptosis in diseases like skin cancer, psoriasis, and systemic lupus erythematosus.