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Autoantigens: The Critical Partner in Initiating and Propagating Systemic Autoimmunity
Author(s) -
DUANPORTER WEI D.,
CASCIOLAROSEN LIVIA,
ROSEN ANTONY
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1358.015
Subject(s) - autoimmunity , immunology , autoantibody , cancer , immunotherapy , self tolerance , autoimmune disease , disease , medicine , cancer immunotherapy , immune system , antibody , pathology
A bstract : The increasing recognition that cancer is frequently associated with an autoantibody response, and observations that systemic autoimmunity is sometimes associated with the diagnosis of a variety of malignancies (many detected near the onset of autoimmune disease), strongly underscore a potential mechanistic connection between cancer immunity and systemic autoimmunity. Accumulating data suggest that autoantigens are critical partners in driving the autoimmune response. Futhermore, unique changes in antigen expression and conformation in the immunizing tumor and the target tissue may play a role in antigen selection and ongoing damage. This construct has important implications for disgnosis, monitoring, and treatment of autoimmunity and, potentially, cancer immunotherapy.