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Central and Peripheral Effects of Insulin/IGF‐1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens
Author(s) -
ANISIMOV VLADIMIR N.,
BERSTEIN LEV M.,
POPOVICH IRINA G.,
ZABEZHINSKI MARK A.,
EGORMIN PETER A.,
TYNDYK MARGARITA L.,
ANIKIN IVAN V.,
SEMENCHENKO ANNA V.,
YASHIN ANATOLI I.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1356.017
Subject(s) - longevity , insulin , hyperinsulinemia , insulin receptor , life span , klotho , caloric theory , diabetes mellitus , endocrinology , biology , calorie restriction , insulin like growth factor , cancer , medicine , signal transduction , growth factor , receptor , pharmacology , microbiology and biotechnology , genetics , insulin resistance , evolutionary biology , kidney
Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. Insulin/insulin‐like growth factor 1 (IGF‐1) signaling molecules linked to longevity include DAF‐2 and insulin receptor (InR) and their homologues in mammals and to inactivation of the corresponding genes followed by increased life span in nematodes, fruit flies, and mice. It is possible that the life‐prolonging effect of caloric restriction are due to decreasing IGF‐1 levels. A search of pharmacological modulators of life span‐extending mutations in the insulin/IGF‐1 signaling pathway and mimetics of effects of caloric restriction could be a direction in the regulation of longevity. Some literature and our own observations suggest that antidiabetic drugs could be promising candidates for both life span extension and prevention of cancer.