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Protection of Proteins from Oxidative Stress: A New Illusion or a Novel Strategy?
Author(s) -
BOLDYREV ALEXANDER A.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1356.013
Subject(s) - oxidative stress , oxidative phosphorylation , carnosine , chemistry , antioxidant , protein aggregation , biochemistry , glycation , receptor
Proteins damaged by oxidative stress have the most dangerous consequences. Oxidized protein derivatives inveigle lipids and carbohydrates into metabolic transformations that result in loss of protein functions and accumulation of glycated proteins and advanced glycated end products, which are difficult to remove from living tissues. Hydrophobic antioxidants are not very effective in protecting proteins from oxidative modification. At the same time, the natural hydrophilic antioxidant and anti‐glycating agent carnosine efficiently prevents oxidative modification of proteins and increases the life span of experimental animals under unfavorable conditions. It can be considered a potent natural geroprotector.