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Cytokine Responses in Dogs Infected with Ehrlichia canis Oklahoma Strain
Author(s) -
TAJIMA TOMOKO,
RIKIHISA YASUKO
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1355.078
Subject(s) - ehrlichia canis , ehrlichiosis , canis , peripheral blood mononuclear cell , immune system , immunology , cytokine , antibody , biology , virology , pathogen , ehrlichia , interferon gamma , microbiology and biotechnology , in vitro , serology , paleontology , biochemistry , tick
A bstract :Ehrlichia canis causes persistent infection of monocytes/macrophages and causes canine monocytic ehrlichiosis. Other than antibody development, very little is known how the dog immune system responds to this pathogen. In the present study, we examined the temporal expression of cytokine mRNA in peripheral blood mononuclear cells (PBMCs) from dogs inoculated with E. canis Oklahoma strain. We also examined production of interferon‐gamma (IFN‐γ) by canine PBMCs infected with E. canis in vitro .