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Analysis of Ehrlichial p28 Gene Expression in a Murine Model of Persistent Infection
Author(s) -
CROCQUETVALDES PATRICIA A.,
McBRIDE JERE W.,
FENG HUIMIN,
ISMAIL NAHED,
SMALL MELISSA A.,
YU XUEJIE,
WALKER DAVID H.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1355.076
Subject(s) - orfs , biology , ehrlichia , locus (genetics) , genetics , gene , intergenic region , virology , open reading frame , tick , genome , peptide sequence
A bstract : Historically, ehrlichioses were tick‐borne diseases of veterinary medical importance and are now important emerging infectious diseases in humans. p28s are encoded by multigene families with ORFs tandemly arranged with intergenic spaces of variable lengths. We reported initial sequencing of the Ehrlichia muris p28 locus. A model of persistent infection was described and provided tools for study of persistent ehrlichial infection. We completed the sequence of the E. muris p28 locus and examined mRNA expression.