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Short‐ and Long‐Term Immune Responses of CD‐1 Outbred Mice to the Scrub Typhus DNA Vaccine Candidate: p47Kp
Author(s) -
XU GUANG,
CHATTOPADHYAY SUCHISMITA,
JIANG JU,
CHAN TEIKCHYE,
CHAO CHIENCHUNG,
CHING WEIMEI,
RICHARDS ALLEN L.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1355.043
Subject(s) - immune system , scrub typhus , dna vaccination , term (time) , virology , immunology , biology , typhus , immunization , physics , quantum mechanics
A bstract :Orientia tsutsugamushi is an obligate intracellular bacterium that is the causative agent of scrub typhus. To develop an effective vaccine to prevent or ameliorate scrub typhus, knowledge of the protective immune response to O. tsutsugamushi needs to be ascertained. Our laboratory has demonstrated that the DNA vaccine vector pVR1012 carrying the O. tsutsugamushi Karp strain 47‐kDa protein gene (p47Kp) consistently provides outbred mice protection against homologous challenge.