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Structural Features of Lipopolysaccharide from Rickettsia Typhi : The Causative Agent of Endemic Typhus
Author(s) -
FODOROVA MARCELA,
VADOVIC PAVOL,
SKULTETY LUDOVIT,
SLABA KATARINA,
TOMAN RUDOLF
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1355.041
Subject(s) - rickettsia typhi , typhus , microbiology and biotechnology , murine typhus , virology , rickettsia , salmonella typhi , biology , lipopolysaccharide , immunology , virus , genetics , escherichia coli , gene
A bstract :Rickettsia typhi causes endemic typhus, a relatively mild, acute febrile illness characterized by headache and macular rash. It is maintained in rodents and transmitted to humans by flea Xenopsylla cheopis . R. typhi contains a lipopolysaccharide thought to display a noticeable antigenic activity. We examined its structural features and it appears that the O‐specific chain of the R. typhi LPS is composed mainly of the alternating Glc and QuiNAc residues linked by 1→4 bonds.