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Age‐Dependent Effects of in Vitro Radiofrequency Exposure (Mobile Phone) on CD95+ T Helper Human Lymphocytes
Author(s) -
CAPRI MIRIAM,
SALVIOLI STEFANO,
ALTILIA SERENA,
SEVINI FEDERICA,
REMONDINI DANIEL,
MESIRCA PIETRO,
BERSANI FERDINANDO,
MONTI DANIELA,
FRANCESCHI CLAUDIO
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1354.071
Subject(s) - peripheral blood mononuclear cell , cd28 , in vitro , cd8 , immune system , fas receptor , stimulation , lymphocyte , downregulation and upregulation , il 2 receptor , chemistry , immunology , endocrinology , medicine , t cell , apoptosis , programmed cell death , biochemistry , gene
Abstract: Recent studies on “nonthermal” effects of mobile phone radiofrequency (RF) suggest that RF can interact with cellular functions and molecular pathways. To study the possible RF effects on human lymphocyte activation, we analyzed CD25, CD95, CD28 molecules in unstimulated and stimulated CD4+ e CD8+ T cells in vitro . Peripheral blood mononuclear cells (PBMCs) from young and elderly donors were exposed or sham‐exposed to RF (1,800 MHz, Specific Absorption Rate 2 W/kg) with or without mitogenic stimulation. No significant changes in the percentage of these cell subsets were found between exposed and sham‐exposed lymphocytes in both young and elderly donors. Nevertheless, after RF exposure we observed a slight, but significant, downregulation of CD95 expression in stimulated CD4+ T lymphocytes from elderly, but not from young donors. This age‐related result is noteworthy given the importance of a such molecule in regulation of the immune response.