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Heat‐Shock Protein 70 Genes and Human Longevity
Author(s) -
SINGH RIPUDAMAN,
KØLVRAA STEEN,
BROSS PETER,
CHRISTENSEN KAARE,
GREGERSEN NIELS,
TAN QIHUA,
JENSEN UFFE BIRK,
EIBERG HANS,
RATTAN SURESH I. S.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1354.040
Subject(s) - longevity , single nucleotide polymorphism , heat shock protein , haplotype , biology , peripheral blood mononuclear cell , gene , hsp70 , genotype , shock (circulatory) , genetics , population , medicine , in vitro , environmental health
We have studied the association of three single nucleotide polymorphisms (SNPs) present in the three HSP70 (heat‐shock protein) genes on 6p21 with human longevity. The availability of biological samples from various population cohorts in Denmark has given us the opportunity to try novel methods of gene association with human longevity. A significant association of one haplotype with male longevity was observed. Furthermore, a significant difference in the survival of the carriers of the different genotypes in females was observed. We also found an age‐dependant decline in the ability of peripheral blood mononuclear cells to respond to heat stress in terms of Hsp70 induction.