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Frequency of Polymorphisms of Signal Peptide of TGF‐β1 and −1082G/A SNP at the Promoter Region of Il‐10 Gene in Patients with Carotid Stenosis
Author(s) -
CRIVELLO ANTONIO,
GIACALONE ANTONIO,
SCOLA LETIZIA,
FORTE GIUSI IRMA,
NUZZO DOMENICO,
GIACCONI ROBERTINA,
CIPRIANO CATIA,
CANDORE GIUSEPPINA,
MOCCHEGIANI EUGENIO,
ROMANO GIUSEPPINA COLONNA,
LIO DOMENICO,
CARUSO CALOGERO
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1354.038
Subject(s) - single nucleotide polymorphism , snp , haplotype , allele , inflammation , gene , polymorphism (computer science) , genetics , biology , genotype , medicine , immunology
The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF‐β1 gene and −1082G/A SNP at IL‐10 promoter sequence, two well‐known immunosuppressive and anti‐inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF‐β1 and IL‐10 polymorphisms in atherosclerosis.