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Opposite Role of Pro‐Inflammatory Alleles in Acute Myocardial Infarction and Longevity
Author(s) -
CANDORE GIUSEPPINA,
BALISTRERI CARMELA RITA,
GRIMALDI MARIA PAOLA,
LISTÌ FLORINDA,
VASTO SONYA,
CARUSO MARCO,
CAIMI GREGORIO,
HOFFMANN ENRICO,
COLONNAROMANO GIUSEPPINA,
LIO DOMENICO,
PAOLISSO GIUSEPPE,
FRANCESCHI CLAUDIO,
CARUSO CALOGERO
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1354.035
Subject(s) - longevity , centenarian , allele , myocardial infarction , disease , proinflammatory cytokine , offspring , medicine , genotype , biology , immunology , genetics , inflammation , gene , pregnancy
The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro‐inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age‐associated diseases that are characterized by a multifactorial etiology.