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Search for Genetic Factors Associated with Susceptibility to Multiple Sclerosis
Author(s) -
FORTE GIUSI IRMA,
RAGONESE PAOLO,
SALEMI GIUSEPPE,
SCOLA LETIZIA,
CANDORE GIUSEPPINA,
D'AMELIO MARCO,
CRIVELLO ANTONIO,
DI BENEDETTO NORMA,
NUZZO DOMENICO,
GIACALONE ANTONIO,
LIO DOMENICO,
CARUSO CALOGERO
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1354.034
Subject(s) - single nucleotide polymorphism , multiple sclerosis , cytokine , genotype , pathogenesis , immunology , biology , genetics , tumor necrosis factor alpha , genetic predisposition , disease , gene , medicine , pathology
Multiple sclerosis (MS) is a cell‐mediated autoimmune disease characterized by type‐1 cytokine production. Environmental and individual genetic background might influence this response particularly in cytokine gene polymorphisms. We evaluated whether polymorphisms of interleukin (IL)‐10, IL‐12, and tumor necrosis factor (TNF)‐α genes, which might play a role in MS pathogenesis, are associated with MS susceptibility. Genotype frequencies for all the analyzed polymorphisms were not differently distributed between cases and controls. It is reasonable to suppose that the cytokine single‐nucleotide polymorphisms (SNPs) studied must be considered against a larger genetic background involving other functional SNPs of Th1 regulator elements such as IL‐21 and IL‐23.