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CARF Regulates p19ARF‐p53‐p21WAF1 Senescence Pathway by Multiple Checkpoints
Author(s) -
KAUL SUNIL C.,
HASAN KAMRUL,
WADHWA RENU
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1354.026
Subject(s) - nucleoplasm , chemistry , microbiology and biotechnology , function (biology) , senescence , cytoplasm , biochemistry , biology , nucleolus
CARF was first cloned as a novel binding partner of ARF from a yeast‐interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. We demonstrate that p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
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