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Establishment of H 2 O 2 ‐Induced Premature Senescence in Human Fibroblasts Concomitant with Increased Cellular Production of H 2 O 2
Author(s) -
ZDANOV STEPHANIE,
REMACLE JOSE,
TOUSSAINT OLIVIER
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1354.025
Subject(s) - senescence , chemistry , concomitant , microbiology and biotechnology , biology , medicine
Premature senescence of human fibroblasts is established after exposure to an acute sublethal concentration of H 2 O 2 . Overexpression of transforming growth factor‐β1 (TGF‐β1) was shown to be responsible for the appearance of the biomarkers of senescence in these conditions. Other studies have shown that incubation of human fibroblasts with TGF‐β1 leads to overexpression of H 2 O 2 . In this work, we show an increased production of H 2 O 2 by human fibroblasts as premature senescence is established after an initial exposure to H 2 O 2 .