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OXPHOS Supercomplexes
Author(s) -
KRAUSE FRANK,
SCHECKHUBER CHRISTIAN Q.,
WERNER ALEXANDRA,
REXROTH SASCHA,
REIFSCHNEIDER NICOLE H.,
DENCHER NORBERT A.,
OSIEWACZ HEINZ D.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1354.013
Subject(s) - podospora anserina , alternative oxidase , ubiquinol , respiratory chain , electron transport chain , biochemistry , oxidative phosphorylation , mitochondrion , mutant , biology , cytochrome c oxidase , atp synthase , bioenergetics , electron transport complex iv , chemistry , microbiology and biotechnology , coenzyme q – cytochrome c reductase , enzyme , cytochrome c , gene
Recent biochemical evidence has indicated the existence of respiratory supercomplexes as well as ATP synthase oligomers in the inner mitochondrial membrane of different eukaryotes. We have studied the organization of the respiratory chain of a wild‐type strain and of two long‐lived mutants of the filamentous fungus Podospora anserina . This aging model is able to respire by either the standard or the alternative pathway. In the latter, electrons are directly transferred from ubiquinol to the alternative oxidase (AOX) and thus bypass complexes III and IV. We showed that the two pathways are composed of distinct respiratory supercomplexes. These data are of significance for the understanding of both respiratory pathways as well as of life‐span control and aging.