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Inadequate Intensity of Various Components of Total Environmental Signals Can Lead to Natural Aging
Author(s) -
KHALYAVKIN ALEXANDER V.,
YASHIN ANATOLI I.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1354.007
Subject(s) - organism , natural (archaeology) , lead (geology) , mode (computer interface) , ecology , order (exchange) , environmental science , computer science , biological system , biology , economics , paleontology , finance , operating system
We suppose that natural aging derives from an inevitable shift in certain parameters of physiological control systems under the influence of inadequate environmental conditions, which are not able to fully induce an organism's “optimal” existence in the self‐maintenance mode. In this case the rate of aging is proportional to the multidimensional difference between the cues from evolutionarily designed adequate habitat and signals from the real environment. The negative correlation between parameters of Gompertzian mortality (and some other published findings) is compatible with this view. Here we discuss examples from intracellular to organism level in order to show that adequate patterns of outer signals can reverse some aging manifestations.