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Animal Models of Pheochromocytoma Including NIH Initial Experience
Author(s) -
OHTA SHOICHIRO,
LAI EDWIN W.,
TANIGUCHI SHUN'ICHIRO,
TISCHLER ARTHUR S.,
ALESCI SALVATORE,
PACAK KAREL
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1353.034
Subject(s) - pheochromocytoma , animal model , medicine , pathology , catecholamine , cancer research , biology
Mouse models have been used to study the mechanisms underlying the carcinogenesis of a wide variety of human cancer. A considerable number of mouse and rat models, used for the study of elementary tumorgenic mechanisms, were found to develop pheochromocytomas. Some of these models resemble hereditary syndrome‐related pheochromocytoma in humans and some may serve as a new starting point for human pheochromocytoma research. Recently, we generated a model of catecholamine‐producing metastatic pheochromocytoma in athymic nude mice using tail‐vein injection of mouse pheochromocytoma cells (MPCs). This and alternative animal models of metastatic pheochromocytoma are promising avenues in preclinical studies to evaluate new therapeutic approaches for malignant pheochromocytoma.