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Expression and Effect of Transforming Growth Factor‐α and Tumor Necrosis Factor‐α in Human Pheochromocytoma
Author(s) -
TONG ANLI,
ZENG ZHENGPEI,
LI HANZHONG,
YANG DI,
LU LIN,
LI MING
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1353.031
Subject(s) - pheochromocytoma , transforming growth factor , tumor necrosis factor alpha , tumor necrosis factor α , cancer research , growth factor , nerve growth factor , medicine , endocrinology , biology , receptor
This study observed the expression of transforming growth factor‐α (TGF‐α) and tumor necrosis factor‐α (TNF‐α) in pheochromocytoma (PHEO) tissue and examined their effects on the proliferation and apoptosis of human PHEO cells. The mRNA and protein expressions of TGF‐α and TNF‐α were higher in PHEO tissues than in normal adrenal medullary tissues, and their expressions varied with pathological features. TGF‐α and TNF‐α stimulated the proliferation of primary human PHEO cells, but had no effect on the cell apoptosis. Both TGF‐α and TNF‐α might be involved in the pathogenesis of human PHEO. TNF‐α needs to be further investigated before its treatment of PHEO can be realized in clinical practice.