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Expression and Effect of Adrenomedullin in Pheochromocytoma
Author(s) -
ZENG ZHENGPEI,
LIU DONGMEI,
LI HANZHONG,
FAN XINRONG,
LIU GUOQIANG,
YAN WEIGANG,
TONG ANLI,
ZHENG XIN
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1353.030
Subject(s) - adrenomedullin , pheochromocytoma , medicine , paracrine signalling , autocrine signalling , endocrinology , chemistry , receptor , tropoelastin , messenger rna , extracellular matrix , biochemistry , gene
This study investigates the expression of human adrenomedullin (ADM) and its receptor–receptor activity modifying protein 2/calcitonin receptor‐like receptor (RAMP2/CRLR) mRNA in pheochromocytoma by reverse transcriptase polymerase chain reaction (RT‐PCR) and its effect on the proliferation of pheochromocytoma cells by MTT. The mRNA expression of ADM and its receptor RAMP2/CRLR was present in normal adrenal medulla and pheochromocytoma tissues. The mRNA expression of ADM, RAMP2, and CRLR is markedly higher in pheochromocytomas than in normal medulla. ADM inhibits the proliferation of human pheochromocytoma cells and exerts a possible autocrine or paracrine effect in the adrenal.