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Thiolsulfinate Allicin from Garlic: Inspiration for a New Antimicrobial Agent
Author(s) -
HUNTER ROGER,
CAIRA MINO,
STELLENBOOM NASHIA
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1352.011
Subject(s) - allicin , antimicrobial , chemistry , combinatorial chemistry , class (philosophy) , biochemistry , organic chemistry , computer science , artificial intelligence
Consideration of the underlying features responsible for garlic‐allicin's antimicrobial activity as well as its instability has prompted an investigation into substituted S ‐aryl alkylthiolsulfinates as a class of garlic mimic with enhanced stability. Synthesis of the targets has inspired the development of new methods for synthesizing unsymmetrical aralkyl disulfides, which are then oxidized to the targets. Some simple representatives have been synthesized, setting the scene for a full SAR study of this relatively unexplored class of thiolsulfinate.