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Cell Stress Response in Skeletal Muscle Myofibers
Author(s) -
TARRICONE ELENA,
GHIRARDELLO ANNA,
ZAMPIERI SANDRA,
ELISA RAMPUDDA MARIA,
DORIA ANDREA,
GORZA LUISA
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1351.046
Subject(s) - skeletal muscle , endoplasmic reticulum , microbiology and biotechnology , homeostasis , biology , unfolded protein response , cell , myocyte , stimulus (psychology) , cell type , endocrinology , biochemistry , psychology , psychotherapist
Cells respond to conditions that impair homeostasis through ex novo synthesis of stress proteins, which differ in subcellular localization and biological function and whose differential expression depends on the type of the stressing stimulus and on the involvement of the specific stress‐response signaling cascade. The biological significance of such an event is the increased resistance against further perturbations of cell homeostasis, and thus, enhanced survival. We will review briefly the available evidence concerning stress response of skeletal muscle cells, including recent results indicating the involvement of endoplasmic reticulum stress response and proteins in skeletal muscle cell differentiation and in progression of muscle diseases.