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Leptin Is a Link between Adipose Tissue and Inflammation
Author(s) -
HÄRLE PETER,
STRAUB RAINER H.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1351.044
Subject(s) - leptin , adipose tissue , immune system , white adipose tissue , inflammation , hormone , medicine , endocrinology , adipokine , biology , mediator , obesity , immunology
Leptin is a hormone of the pluripotent white adipose tissue and confers a multitude of regulatory functions within the organism. It controls the energy storage, lipoprotein metabolism, acute phase reactants, sex hormones and glucocorticoid metabolism, and immune function. In this review, we describe these multiple functions of leptin, the regulation of leptin expression, and how leptin can modulate the immune system via direct and indirect mechanisms. We show how leptin can be a link between the adipose tissue and inflammation.