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The Stem Cell Continuum
Author(s) -
QUESENBERRY PETER J.,
COLVIN GERALD A.,
ABEDI MEHRDAD,
DOONER GERRI,
DOONER MARK,
ALIOTTA JASON,
KEANEY PATRICK,
LUO LUGUANG,
DEMERS DELIA,
PETERSON ABIGAIL,
FOSTER BETHANY,
GREER DEBORAH
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1349.028
Subject(s) - homing (biology) , stem cell , progenitor cell , microbiology and biotechnology , haematopoiesis , biology , cell cycle , endothelial stem cell , stem cell factor , cellular differentiation , cxcr4 , cell , immunology , gene , genetics , in vitro , inflammation , chemokine , ecology
A bstract : Hematopoietic stem cells have been felt to exist in a hierarchical structure with a relatively fixed phenotype at each stage of differentiation. Recent studies on the phenotype of the marrow hematopoietic stem cell indicate that it is not a fixed entity, but rather that it fluctuates and shows marked heterogeneity. Past studies have shown that stem cell engraftment characteristics, adhesion protein, and gene expression varies with the phase of the cell cycle. More recently, we demonstrated that progenitor numbers and differentiation potential also vary reversibly during one cytokine‐induced cell cycle transit. We have also shown high levels of conversion of marrow cells to skeletal muscle and lung cells, indicating a different level of plasticity. Recently, we demonstrated that homing to lung and conversion to lung cells in a mouse transplant model also fluctuates reversibly with cell cycle transit. This could be considered plasticity squared . These data indicate that marrow stem cells are regulated on a continuum related to the cell cycle both as to hematopoietic and to nonhematopoietic differentiation.