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Role of GATA‐1 in Normal and Neoplastic Hemopoiesis
Author(s) -
MIGLIACCIO ANNA RITA,
RANA ROSA ALBA,
VANNUCCHI ALESSANDRO M.,
MANZOLI FRANCESCO A.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1349.019
Subject(s) - haematopoiesis , gata2 , enhancer , biology , transcription factor , mutant , microbiology and biotechnology , gene , genetics , stem cell
A bstract : GATA‐1 exerts a concentration‐dependent control on the differentiation of erythroid, megakaryocytic, mast, and eosinophilic cells. The concentration of GATA‐1 is, in turn, regulated by specific sequences within the GATA‐1 locus. On the basis of its levels of expression, the GATA‐1 protein becomes associated with suitable partners forming transcription complexes that, by binding to lineage‐specific enhancers, activate the expression of the corresponding target genes. Instrumental to our understanding of the role of GATA‐1 in hemopoietic differentiation has been the generation of genetically engineered mutant mice and the discovery of naturally occurring mutations associated with either inherited or acquired human pathologies. We review our current understanding of the role of GATA‐1 in normal and neoplastic hematopoiesis as emerging from these genetic approaches.