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Hematopoietic Stem Cell Transplantation across Major Genetic Barriers: Tolerance Induction by Megadose CD34 Cells and Other Veto Cells
Author(s) -
REISNER YAIR,
GUR HILIT,
REICHZELIGER SHLOMIT,
MARTELLI MASSIMO F.,
BACHARLUSTIG ESTHER
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1349.010
Subject(s) - haematopoiesis , veto , progenitor cell , transplantation , biology , microbiology and biotechnology , immunology , cd34 , ctl* , population , hematopoietic stem cell transplantation , cd8 , stem cell , cancer research , immune system , medicine , political science , environmental health , politics , law
A bstract : Studies in mice and humans demonstrate that transplantation of hematopoietic progenitors in numbers larger than commonly used overcomes major genetic barriers. In vitro studies suggest that veto cells, within the population of hematopoietic progenitors, facilitate this favorable outcome. Tolerance induction can be further enhanced by other veto cells. Perhaps the most potent veto cell is the CD8 + CTL. However, this cell is also associated with marked GVHD, which can be separated from the veto activity by generating anti‐third party CTLs under IL‐2 deprivation.