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Involvement of Proteases in Cytokine‐Induced Hematopoietic Stem Cell Mobilization
Author(s) -
VELDERS GERJO A.,
FIBBE WILLEM E.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1349.008
Subject(s) - proteases , mobilization , haematopoiesis , cytokine , stem cell , hematopoietic stem cell , microbiology and biotechnology , chemistry , immunology , medicine , biology , biochemistry , enzyme , history , archaeology
A bstract : The number of circulating stem cells and progenitor cells can be increased by physiological stress, such as exercise, stress, and infections. The process of shifting the stem cells from the bone marrow into the peripheral blood is referred to as “mobilization” or “egress.” Cytokine‐mobilized hematopoietic progenitor cells (HPCs) are currently used for autologous or allogeneic stem cell transplantation in a variety of malignant and nonmalignant diseases. In spite of the wide‐spread use of mobilized peripheral blood stem cells for transplantation, the mechanisms underlying mobilization are still incompletely understood. Here we discuss the role of neutrophils and proteases as mediators of stem cell mobilization.