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Inhibition of Hepatitis C IRES‐Mediated Gene Expression by Small Hairpin RNAs in Human Hepatocytes and Mice
Author(s) -
ILVES HEINI,
KASPAR ROGER L.,
WANG QIAN,
SEYHAN ATTILA A.,
VLASSOV ALEXANDER V.,
CONTAG CHRISTOPHER H.,
LEAKE DEVIN,
JOHNSTON BRIAN H.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1348.060
Subject(s) - internal ribosome entry site , small hairpin rna , virology , rna , gene expression , biology , hepatitis c virus , microbiology and biotechnology , gene , messenger rna , rna interference , ribosome , virus , genetics
The ability of small hairpin RNAs (shRNAs) to inhibit hepatitis C virus internal ribosome entry site (HCV IRES)‐dependent gene expression was investigated in cultured cells and a mouse model. The results indicate that shRNAs, delivered as naked RNA or expressed from vectors, may be effective agents for the control of HCV and related viruses.