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CpG Oligonucleotides Improve the Protective Immune Response Induced by the Licensed Anthrax Vaccine
Author(s) -
KLINMAN DENNIS M.,
XIE HANG,
IVINS BRUCE E.
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1348.030
Subject(s) - anthrax vaccines , cpg oligodeoxynucleotide , avidity , immune system , antibody response , virology , immunology , antigen , bacillus anthracis , cpg site , antibody , oligonucleotide , medicine , biology , dna vaccination , immunization , dna , biochemistry , gene expression , genetics , dna methylation , bacteria , gene
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, improving the response elicited by a coadministered vaccine. Combining CpG ODN with anthrax vaccine adsorbed (AVA, the licensed human vaccine) increases the speed, magnitude, and avidity of the resultant antibody response. IgG Abs against anthrax protective antigen (PA) protect mice, guinuea pigs, and rhesus macaques from infection.