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IL‐7 Drives T Cell‐Mediated Bone Loss Following Ovariectomy
Author(s) -
ROBBIERYAN MICHAELA,
PACIFICI ROBERTO,
WEITZMANN M. NEALE
Publication year - 2006
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1346.051
Subject(s) - chemistry , microbiology and biotechnology , medicine , biology
Ovariectomy‐induced bone loss stems in large measure from a realignment of adaptive immune responses leading to the activation and expansion of tumor necrosis factor (TNF)‐producing T cells. The mechanisms driving this T cell expansion are complex but we have recently reported that the pro‐osteoclastogenic cytokine interleukin (IL)‐7 plays a critical role in this process. The mechanisms of IL‐7 action are intricate and poorly defined. We present herein an overview of our current understanding of IL‐7 action on bone turnover and the role of IL‐7 in ovariectomy‐induced bone loss.