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Separation of Normoblasts from Whole Blood by Ultracentrifugation on Arabino‐Galactane Discontinuous Gradients: A Tool for Prenatal Diagnosis
Author(s) -
PIOMELLI SERGIO,
HIRSCH DANIEL,
CORASH LAWRENCE
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1345.073
Subject(s) - ultracentrifuge , chromatography , chemistry , prenatal diagnosis , pregnancy , biology , fetus , genetics
A bstract : Normoblasts can be separated at high resolution from whole blood by ultracentrifugation on discontinuous gradients of arabino‐galactane after the red blood cells are removed by sedimentation. With this method, isolation of fetal normoblasts from maternal blood could provide a tool for rapid prenatal diagnosis. The availability of this noninvasive technique could avoid the cost and the risks of miscarriage that are associated with the current invasive procedures.